| # | Building | Images | Height | Floors | Building type | Year | Status |
|---|---|---|---|---|---|---|---|
| 1 | Methodist Outpatient Care Center | 31 | 512 ft | 26 | skyscraper | 2010 | |
| 2 | The O'Quinn Medical Tower at St. Luke's | 15 | 477 ft | 29 | skyscraper | 1990 | |
| 3 | Lester and Sue Smith Legacy Tower | 5 | 457 ft | 25 | skyscraper | 2013 | |
| 4 | Memorial Hermann Medical Plaza | 32 | 430 ft | 28 | skyscraper | 2007 | |
| 5 | The Spires | 4 | 427 ft | 40 | skyscraper | 1983 | |
| 6 | The Spires II | 426 ft | 40 | skyscraper | - | ||
| 7 | M.D. Anderson Cancer Center - Mid-Campus Building One | 29 | 415 ft | 25 | skyscraper | 2012 | |
| 8 | Paula & Rusty Walter Tower | 395 ft | 22 | skyscraper | 2018 | ||
| 9 | Susan and Fayez Sarofim Pavilion | 380 ft | 15 | skyscraper | 2019 | ||
| 10 | Smith Tower | 1 | 367 ft | 26 | skyscraper | 1988 | |
| 11 | TCH West Tower | 5 | 348 ft | 20 | skyscraper | 2001 | |
| 12 | University Center Tower | 2 | 345 ft | 25 | skyscraper | 1974 | |
| 13 | T. Boone Pickens Academic Tower | 1 | 324 ft | 21 | high-rise building | 2008 | |
| 14 | Houston Main Building | 4 | 312 ft | 21 | high-rise building | 1952 | |
| 15 | Houston Marriott Medical Center | 1 | 265 ft | 25 | high-rise building | 1984 | |
| 16 | Vantage Med Center | 1 | 260 ft | 22 | high-rise building | 2017 | |
| 17 | Sheikh Zayed Bin Sultan Al Nahyan Building for Personalized Cancer Care | 260 ft | 14 | high-rise building | 2014 | ||
| 18 | Texas Children's Hospital Mark A. Wallace Tower | 5 | 249 ft | 16 | high-rise building | 2002 | |
| 19 | George and Cynthia Mitchell Basic Sciences Research Building | 3 | 229 ft | 19 | high-rise building | 2004 | |
| 20 | Houston Methodist Research Institute | 3 | 226 ft | 12 | high-rise building | 2010 |