Small community located in Nemaha County. Seneca is located on U.S. Highway 36, once the main road linking Chicago and Denver. There were no hotel "chains" such as Holiday Inn, Best Western and Motel 6 until the 1950's. About that time the USA's interstate system opened, with I-70 paralleling US 36 about 50 miles to the south. As traffic moved to the four-lane interstates and motel chains emerged adjacent to them, independent hotels in small towns began to disappear with the changing times.