| # | Building | Images | Height | Floors | Building type | Year | Status |
|---|---|---|---|---|---|---|---|
| 1 | Transmission Tower | 250 ft | - | mast (framework) | - | ||
| 2 | Transmission Tower | 190 ft | - | mast (framework) | - | ||
| 3 | Transmission Tower | 180 ft | - | mast (framework) | - | ||
| 4 | Genetti Hotel and Suites | 11 | 162 ft | 10 | high-rise building | 1922 | |
| 5 | Transmission Tower | 161 ft | - | mast (framework) | - | ||
| 6 | Williamsport Elderly Housing | 2 | 114 ft | 11 | low-rise building | 1978 | |
| 7 | Center City Building | 6 | 98 ft | 7 | low-rise building | 1892 | |
| 8 | William Hepburn Apartments | 5 | ≈114 ft | 9 | low-rise building | 1969 | |
| 9 | Penn Tower | 9 | 8 | low-rise building | 1913 | ||
| 10 | Third Street Parking Garage | 4 | 7 | open-air structure | 1999 | ||
| 11 | Peter Herdic High-Rise | 3 | ≈89 ft | 7 | low-rise building | - | |
| 12 | Williamsport Hospital - Main Building | 7 | low-rise building | 1925 | |||
| 13 | Susquehanna Heart & Vascular Institute | ≈76 ft | 6 | low-rise building | 2011 | ||
| 14 | American Rescue Workers Building | 2 | 6 | low-rise building | 1901 | ||
| 15 | 500 Arch Street | 3 | 6 | low-rise building | 1920 | ||
| 16 | A. H. Heilman Company Building | 6 | 6 | low-rise building | 1912 | ||
| 17 | 33 West 3rd Street | 3 | ≈76 ft | 6 | low-rise building | 1993 | |
| 18 | Lycoming County Courthouse | ≈51 ft | 4 | low-rise building | 1971 | ||
| 19 | Williamsport City Hall | 4 | 3 | building with towers | 1891 | ||
| 20 | Old City Hall | 4 | 3 | building with towers | 1894 |